E-ISSN: 2980 - 082X
TR EN
DETAILED SEARCH:
REVIEW
A Clinical Approach to The Effect of Boswellia Serrata in Osteoarthritis
Received Date : 29 Apr 2022
Accepted Date : 28 Jun 2022
Available Online : 01 Sep 2022
Abstract Full PDF Similar Articles
Burçin ÖZÜPEKa, Sultan PEKACARa, Didem DELİORMAN ORHANa
aGazi Üniversitesi, Eczacılık Fakültesi, Farmakognozi ABD, Ankara, Türkiye
Doi: 10.56054/ajohoim.2022-90992 - Article's Language: TR
Acad. J. Homeopat. & Integ. Med. 2023;1(1):11-9
ABSTRACT
Osteoarthritis is one of the most common diseases of the musculoskeletal system that reduces the quality of life.In addition to the non-steroidal anti-inflammatory drugs used in the treatment, molecules isolated from natural sources and standardized plant extracts are also considered as new options in the treatment of inflammatory diseases. In this review, it is aimed to present clinical studies on the gumresin of Boswellia serrata, which is used for joint health due to its anti-inflammatory, antiarthritic and analgesic effects, and the active compounds obtained from this resin. In B. serrata gumresin, boswellic acid in pentacyclic triterpenic acid structure inhibits the pro-inflammatory enzyme 5- lipoxygenase and the synthesis of its products, pro-inflammatory cytokines and mediators (tumor necrosis factor α, interleukin-1 Beta (IL-1) and interleukin-6). It has also been found that it provides significant down-regulation of interferon gamma (IFN-), one of the T-lymphocyte activators.. Clinical studies have shown that standardized B. serrata extracts or preparations enriched with active compounds have curative effects on pain, inflammation and quality of life parameters in osteoarthritis, but more comprehensive clinical studies are needed.
Keywords: arthritis; inflammation; Boswellia serrata
REFERENCES
  1. Kimmatkar N, Thawani V, Hingorani L, Khiyani R Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee-a randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3-7. [Crossref]  [PubMed] 
  2. Buckwalter JA, Saltzman C, Brown T The impact of osteoarthritis: implications for research. Clin Orthop Relat Res. 2004;(427 Suppl):6-15. [Crossref]  [PubMed] 
  3. Bilge A, Ulusoy RG, Üstebay S, Öztürk Ö Osteoartrit. Kafkas J. Med. Sci., 2018;8(1):133-142. [Crossref] 
  4. Choubey J, Patel A, Verma MK Phytotherapy in the treatment of arthritis: a review. Int. J. Pharm. Sci. 2013;4(8):2853- 2853-2865
  5. Kizhakkedath R Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep. 2013;8(5):1542-1548. [Crossref]  [PubMed] 
  6. Kharazmi A, Winther K Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology. 1999;7(4):377-386. [Crossref]  [PubMed] 
  7. Ghasemian M, Owlia S, Owlia MB Review of Anti-Inflammatory Herbal Medicines. Adv Pharmacol Sci. 2016;2016:9130979. [Crossref]  [PubMed]  [PMC] 
  8. Beg S, Swain S, Hasan H, Barkat MA, Hussain MS Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacogn Rev. 2011;5(10):120-137. [Crossref]  [PubMed]  [PMC] 
  9. Pekacar S, Bulut S, Özüpek B, Orhan DD Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules. Curr Mol Pharmacol. 2021;14(5):731-745. [Crossref]  [PubMed] 
  10. Siddiqui MZ Boswellia serrata, a potential antiinflammatory agent: An overview. Indian J Pharm Sci. 2011;73(3):255-261.
  11. Sharma A, Mann AS, Gajbhiye V, Kharya MD Phcog Rev.: Plant Review Phytochemical Profile of Boswellia serrata: An overview. Pharmacogn Rev. 2007;1(1):131-142.
  12. Türkiye İlaç ve Tıbbi Cihaz Kurumu. Tıbbi Bitki Monografları; Boswellia serrata. p.1-2.
  13. Sharma A, Chhikara S, Ghodekar SN, Bhatia S, Kharya MD, Gajbhiye V et al. Phytochemical and pharmacological investigations on Boswellia serrata. Pharmacogn Rev. 2009;3(5):206-215.
  14. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011;50(6):349-69. [Crossref]  [PubMed] 
  15. Monograph. Boswellia serrata. Alternative medicine review: A journal of clinical therapeutic, 2008;13(2):165-167.
  16. European Pharmacopoeia Commission. [Indian Frankincense]. In: European Pharmacopoeia, 7th edition (PhEur 7.0). Strasbourg, France: European Directorate for the Quality of Medicines (EDQM); 2010. p. 1152-1153.
  17. Basch E, Boon H, Davies-Heerema T, Foppo I, Hashmi S, Hasskarl J, et al. Boswellia: An evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother. 2004;4(3):63-83. [Crossref] 
  18. Chopra A, Lavin P, Patwardhan B, Chitre D A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004;10(5):236-245. [Crossref]  [PubMed] 
  19. Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian J. Pharmacol. 2007;39(1):27-29. [Crossref] 
  20. Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):1-11. [Crossref]  [PubMed]  [PMC] 
  21. Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377. [Crossref]  [PubMed]  [PMC] 
  22. Gupta PK, Samarakoon SM, Chandola HM, Ravishankar B Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis). Ayu. 2011;32(4):478-482. [Crossref]  [PubMed]  [PMC] 
  23. Vishal AA, Mishra A, Raychaudhuri SP A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-622. [Crossref]  [PubMed]  [PMC] 
  24. Majeed M, Vaidyanathan P, Natarajan S, Majeed S, Vuppala KK Effect of Boswellin® Super on knee pain in Japanese adults: A randomized, double-blind, placebo-controlled trial. Eur. J. Biomed. 2016;3: 293-298.
  25. Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A et al. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol. 2016;29(1):140-146. [Crossref]  [PubMed]  [PMC] 
  26. Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018;18(1):7. [Crossref]  [PubMed]  [PMC] 
  27. Majeed M, Majeed S, Narayanan NK, Nagabhushanam K A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019;33(5):1457-1468. [Crossref]  [PubMed]  [PMC] 
  28. Italiano G, Raimondo M, Giannetti G, Gargiulo A Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study. J Altern Complement Med. 2020;26(2):123-129. [Crossref]  [PubMed] 
  29. Kulkarni PD, Damle ND, Singh S, Yadav KS, Ghante MR, Bhaskar VH et al. Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee. Drug Metab Pers Ther. 2020;35(2). [Crossref]  [PubMed] 
  30. Karlapudi V, Sunkara KB, Konda PR, Sarma KV, Rokkam MP Efficacy and Safety of Aflapin®, a Novel Boswellia serrata extract, in the treatment of osteoarthritis of the knee: a short-term 30-day randomized, double-blind, placebo-controlled clinical study. J Am Coll Nutr J Am Coll Nutr, 2021:1-10. [Crossref]  [PubMed] 
  31. Doğan Z, Saraçoğlu İ. [FFD Monografları Bitkiler ve Etkileri: Boswellia serrata] Ankara: Akademisyen Yayınevi; 2017. p. 171-183.

INDEX